These include Barcelona, Lanzarote and Turin.
It brings Ryanair’s total winter 2022/23 routes from the UK to 449.
It has 90 bases and over 2,500 routes operating across 36 European countries this winter.
To celebrate, Ryanair has launched a seat sale with fares available from £19.99 on new routes for travel from October 2022 until March 2023.
Ryanair’s Director of Commercial, Jason McGuinness said: “Although this schedule offers plenty of choice, demand is growing swiftly.”